Enantioselective Addition Reaction of Trimethylsilyl Cyanide with Aldehydes Using a Chiral Tin(II) Lewis Acid
نویسندگان
چکیده
منابع مشابه
Kinetics and mechanism of the racemic addition of trimethylsilyl cyanide to aldehydes catalysed by Lewis bases.
The mechanism by which four Lewis bases, triethylamine, tetrabutylammonium thiocyanate, tetrabutylammonium azide and tetrabutylammonium cyanide, catalyse the addition of trimethylsilyl cyanide to aldehydes is studied by a combination of kinetic and spectroscopic methods. The reactions can exhibit first or second order kinetics corresponding to three different reaction mechanisms. Spectroscopic ...
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A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly cata...
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 1991
ISSN: 0366-7022,1348-0715
DOI: 10.1246/cl.1991.541